Gene information
Official symbol SERPINE1
Official full name serpin family E member 1
Gene type protein-coding gene
Chromosome7q22.1
Alias symbolPAI
Previous symbolPLANH1; PAI1
Gene familySerpin peptidase inhibitors
Resources
Entrez Gene 5054
HGNC HGNC:8583
Ensembl ENSG00000106366
Vega OTTHUMG00000157107
UCSC uc003uxt.4
GO terms: 126 records
GO Description Category LogP Number of genes Detail
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0001952 regulation of cell-matrix adhesion GO Biological Processes -7.29794194 21 More
GO:0001953 negative regulation of cell-matrix adhesion GO Biological Processes -4.47602531 9 More
GO:0002020 protease binding GO Molecular Functions -28.8254555 31 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002687 positive regulation of leukocyte migration GO Biological Processes -31.0737422 33 More
GO:0002688 regulation of leukocyte chemotaxis GO Biological Processes -31.6279962 32 More
GO:0002690 positive regulation of leukocyte chemotaxis GO Biological Processes -28.1480961 27 More
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0004866 endopeptidase inhibitor activity GO Molecular Functions -20.0646267 27 More
GO:0004867 serine-type endopeptidase inhibitor activity GO Molecular Functions -8.20238048 12 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010469 regulation of signaling receptor activity GO Biological Processes -13.5880476 20 More
GO:0010755 regulation of plasminogen activation GO Biological Processes -10.5063145 8 More
GO:0010757 negative regulation of plasminogen activation GO Biological Processes -7.90707903 5 More
GO:0010810 regulation of cell-substrate adhesion GO Biological Processes -12.3653476 37 More
GO:0010812 negative regulation of cell-substrate adhesion GO Biological Processes -8.89322529 17 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0010955 negative regulation of protein processing GO Biological Processes -5.65848894 6 More
GO:0014910 regulation of smooth muscle cell migration GO Biological Processes -16.4082106 27 More
GO:0016525 negative regulation of angiogenesis GO Biological Processes -31.9326641 51 More
GO:0030100 regulation of endocytosis GO Biological Processes -14.0757782 22 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030193 regulation of blood coagulation GO Biological Processes -37.6853179 30 More
GO:0030194 positive regulation of blood coagulation GO Biological Processes -18.9359595 14 More
GO:0030195 negative regulation of blood coagulation GO Biological Processes -29.1940441 22 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030414 peptidase inhibitor activity GO Molecular Functions -19.6181890 27 More
GO:0030856 regulation of epithelial cell differentiation GO Biological Processes -15.4645914 35 More
GO:0030858 positive regulation of epithelial cell differentiation GO Biological Processes -9.94639997 18 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031091 platelet alpha granule GO Cellular Components -43.3287145 36 More
GO:0031093 platelet alpha granule lumen GO Cellular Components -40.0105787 31 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032677 regulation of interleukin-8 production GO Biological Processes -20.0046302 33 More
GO:0032757 positive regulation of interleukin-8 production GO Biological Processes -14.6396218 15 More
GO:0033628 regulation of cell adhesion mediated by integrin GO Biological Processes -4.66823778 6 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042475 odontogenesis of dentin-containing tooth GO Biological Processes -4.56077482 13 More
GO:0042476 odontogenesis GO Biological Processes -9.69427751 24 More
GO:0042730 fibrinolysis GO Biological Processes -16.7830831 11 More
GO:0042742 defense response to bacterium GO Biological Processes -25.9215771 41 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0045807 positive regulation of endocytosis GO Biological Processes -11.0143833 14 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0048259 regulation of receptor-mediated endocytosis GO Biological Processes -11.3903749 15 More
GO:0048260 positive regulation of receptor-mediated endocytosis GO Biological Processes -10.1090317 11 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050818 regulation of coagulation GO Biological Processes -40.0839917 32 More
GO:0050819 negative regulation of coagulation GO Biological Processes -31.8350192 24 More
GO:0050820 positive regulation of coagulation GO Biological Processes -18.6547980 14 More
GO:0050829 defense response to Gram-negative bacterium GO Biological Processes -15.0142277 17 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050921 positive regulation of chemotaxis GO Biological Processes -35.4880405 36 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0051917 regulation of fibrinolysis GO Biological Processes -20.6622986 13 More
GO:0051918 negative regulation of fibrinolysis GO Biological Processes -14.1555780 9 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0060627 regulation of vesicle-mediated transport GO Biological Processes -25.1756709 46 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0061043 regulation of vascular wound healing GO Biological Processes -4.91299256 6 More
GO:0061044 negative regulation of vascular wound healing GO Biological Processes -4.05291246 3 More
GO:0061045 negative regulation of wound healing GO Biological Processes -28.2986689 25 More
GO:0061134 peptidase regulator activity GO Molecular Functions -19.3582235 29 More
GO:0061135 endopeptidase regulator activity GO Molecular Functions -19.1908633 27 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070613 regulation of protein processing GO Biological Processes -7.71267127 10 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071675 regulation of mononuclear cell migration GO Biological Processes -19.9332328 23 More
GO:0071677 positive regulation of mononuclear cell migration GO Biological Processes -15.5919825 16 More
GO:0090025 regulation of monocyte chemotaxis GO Biological Processes -10.2459261 9 More
GO:0090026 positive regulation of monocyte chemotaxis GO Biological Processes -11.8198427 9 More
GO:0090303 positive regulation of wound healing GO Biological Processes -15.9447313 16 More
GO:0090399 replicative senescence GO Biological Processes -2.96024730 3 More
GO:0097179 protease inhibitor complex GO Cellular Components -5.88286021 4 More
GO:1900046 regulation of hemostasis GO Biological Processes -39.0044157 31 More
GO:1900047 negative regulation of hemostasis GO Biological Processes -30.8008788 23 More
GO:1900048 positive regulation of hemostasis GO Biological Processes -18.9359595 14 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1901343 negative regulation of vasculature development GO Biological Processes -32.5354692 52 More
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO Biological Processes -11.7829637 12 More
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO Biological Processes -8.64891123 8 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903035 negative regulation of response to wounding GO Biological Processes -27.3379640 26 More
GO:1903036 positive regulation of response to wounding GO Biological Processes -14.4451296 16 More
GO:1903317 regulation of protein maturation GO Biological Processes -7.52692728 10 More
GO:1903318 negative regulation of protein maturation GO Biological Processes -5.65848894 6 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:1904035 regulation of epithelial cell apoptotic process GO Biological Processes -21.2824424 33 More
GO:1904036 negative regulation of epithelial cell apoptotic process GO Biological Processes -12.0631217 12 More
GO:1904090 peptidase inhibitor complex GO Cellular Components -5.67855223 6 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000181 negative regulation of blood vessel morphogenesis GO Biological Processes -32.6997315 52 More
GO:2000351 regulation of endothelial cell apoptotic process GO Biological Processes -18.6276983 25 More
GO:2000352 negative regulation of endothelial cell apoptotic process GO Biological Processes -10.8868003 10 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
GO:2001236 regulation of extrinsic apoptotic signaling pathway GO Biological Processes -20.7647111 26 More
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO Biological Processes -19.1764933 21 More
KEGG pathways: 8 records
KEGG Description Category LogP Number of genes Detail
hsa04066 HIF-1 signaling pathway KEGG Pathway -20.6790877 23 More
hsa04115 p53 signaling pathway KEGG Pathway -6.32340535 9 More
hsa04218 Cellular senescence KEGG Pathway -5.14633043 11 More
hsa04371 Apelin signaling pathway KEGG Pathway -6.49715749 12 More
hsa04390 Hippo signaling pathway KEGG Pathway -3.46529255 17 More
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
hsa04933 AGE-RAGE signaling pathway in diabetic complications KEGG Pathway -25.8646207 26 More
hsa05142 Chagas disease KEGG Pathway -21.3868632 23 More
Drug-Gene interaction
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Related drugs: 20 records
Related studies: 69 records
Molecular factor Omics type Application Objective MI type Reference
NM_000602.5:c.-844G>A genomics myocardial infarction[diagnosis] myocardial infarction Abboud N et al. Genet Test Mol Biomarkers. 2010
NM_000602.5:c.[43G>A;*722T>G] genomics body mass index[other] myocardial infarction Morange PE et al. Arterioscler Thromb Vasc Biol. 2007
NM_000602.5:c.[43G>A;*722T>G] genomics insulin[other] myocardial infarction Morange PE et al. Arterioscler Thromb Vasc Biol. 2007
NM_000602.5:c.[-844A>G;506-451G>A;1088-106A>G] genomics plasminogen activator inhibitor 1[other] myocardial infarction Morange PE et al. Arterioscler Thromb Vasc Biol. 2007
NM_000602.5:c.[-844A>G;701-340G>A] genomics myocardial infarction[diagnosis] myocardial infarction Morange PE et al. Arterioscler Thromb Vasc Biol. 2007
plasminogen activator inhibitor 1 proteomics infarct-related artery patency[prognosis (good)] acute myocardial infarction Andreotti F et al. Thromb Haemost. 1992
plasminogen activator inhibitor 1 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Sakamoto T et al. Am J Cardiol. 1992
plasminogen activator inhibitor 1 proteomics infarct-related artery patency[prognosis (good)] acute ST elevation myocardial infarction Sakamoto T et al. Am J Cardiol. 1992
plasminogen activator inhibitor 1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Chen HZ et al. Chin Med J (Engl). 1990
plasminogen activator inhibitor 1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Almer LO et al. Thromb Res. 1987
plasminogen activator inhibitor 1 proteomics percutaneous transluminal coronary angioplasty[treatment (surgery)] acute myocardial infarction Hara M et al. Cardiology. 1995
plasminogen activator inhibitor 1 proteomics cardiovascular death[prognosis (bad)] acute myocardial infarction Malmberg K et al. J Am Coll Cardiol. 1994
plasminogen activator inhibitor 1 proteomics recurrent myocardial infarction[prognosis (bad)] acute myocardial infarction Malmberg K et al. J Am Coll Cardiol. 1994
plasminogen activator inhibitor 1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Moreno JA et al. Sangre (Barc). 1994
plasminogen activator inhibitor 1 proteomics thrombolytic agent[treatment (pharmacotherapy)] acute ST elevation myocardial infarction Goto S et al. Cardiology. 1993
plasminogen activator inhibitor 1 proteomics diabetes mellitus[prognosis (bad)] acute myocardial infarction Gray RP et al. Br Heart J. 1993
plasminogen activator inhibitor 1 proteomics old myocardial infarction[diagnosis] old myocardial infarction Rallidis LS et al. Thromb Haemost. 1996
plasminogen activator inhibitor 1 proteomics imidapril[treatment (pharmacotherapy)] acute ST elevation myocardial infarction Oshima S et al. Am Heart J. 1997
plasminogen activator inhibitor 1 proteomics silent myocardial ischemia[other] old myocardial infarction Grzywacz A et al. Blood Coagul Fibrinolysis. 1998
plasminogen activator inhibitor 1 proteomics myocardial infarction[diagnosis] myocardial infarction Freeburn JC et al. Br J Haematol. 1998
plasminogen activator inhibitor 1 proteomics cardiorenal syndrome type 1[prognosis (bad)] myocardial infarction Scarabin PY et al. Thromb Haemost. 1998
plasminogen activator inhibitor 1 proteomics captopril[treatment (pharmacotherapy)] acute myocardial infarction Moriyama Y et al. Coron Artery Dis. 1998
plasminogen activator inhibitor 1 proteomics streptokinase[treatment (pharmacotherapy)] acute myocardial infarction Sinkovic A et al. Clin Cardiol. 2000
plasminogen activator inhibitor 1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Soeki T et al. Jpn Circ J. 2000
plasminogen activator inhibitor 1 proteomics death[prognosis (bad)] acute myocardial infarction Sinkovic A. Blood Coagul Fibrinolysis. 2002
plasminogen activator inhibitor 1 proteomics atrial arrhythmia[prognosis (bad)] acute myocardial infarction Sinkovic A. Blood Coagul Fibrinolysis. 2002
plasminogen activator inhibitor 1 proteomics myocardial infarction[diagnosis] myocardial infarction Leander K et al. Thromb Haemost. 2003
plasminogen activator inhibitor 1 proteomics death[prognosis (bad)] acute ST elevation myocardial infarction Collet JP et al. Circulation. 2003
plasminogen activator inhibitor 1 proteomics activated protein C[treatment (pharmacotherapy)] acute ST elevation myocardial infarction Sakamoto T et al. J Am Coll Cardiol. 2003
plasminogen activator inhibitor 1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Rott D et al. Cardiology. 2009
plasminogen activator inhibitor 1 proteomics ramipril[treatment (pharmacotherapy)] acute myocardial infarction Sinkovic A. Wien Klin Wochenschr. 2010
plasminogen activator inhibitor 1 proteomics glucose intolerance[prognosis (bad)] acute ST elevation myocardial infarction Knudsen EC et al. J Thromb Haemost. 2011
plasminogen activator inhibitor 1 proteomics myocardial infarction[diagnosis] myocardial infarction Erzen B et al. Heart Vessels. 2013
plasminogen activator inhibitor 1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Habib SS et al. J Pak Med Assoc. 2012
plasminogen activator inhibitor 1 proteomics myocardial infarction[diagnosis] myocardial infarction Gruzdeva O et al. Diabetes Metab Syndr Obes. 2013
plasminogen activator inhibitor 1 proteomics type 2 diabetes mellitus[prognosis (bad)] myocardial infarction Gruzdeva O et al. Diabetes Metab Syndr Obes. 2013
plasminogen activator inhibitor 1 proteomics poor predictor myocardial infarction[diagnosis] myocardial infarction Knudsen A et al. Aids. 2014
plasminogen activator inhibitor 1 proteomics endothelial dysfunction[prognosis (bad)] acute myocardial infarction Shimizu T et al. J Atheroscler Thromb. 2016
plasminogen activator inhibitor 1 proteomics left ventricular dysfunction[prognosis (bad)] acute myocardial infarction Shimizu T et al. J Atheroscler Thromb. 2016
plasminogen activator inhibitor 1 proteomics medium predictor death[prognosis (bad)] acute ST elevation myocardial infarction Pavlov M et al. Croat Med J. 2018
tissue plasminogen activator/plasminogen activator inhibitor-1 complex proteomics recurrent myocardial infarction[prognosis (bad)] myocardial infarction Wiman B et al. Arterioscler Thromb Vasc Biol. 2000
NM_000602.5:c.*722T>G genomics myocardial infarction[diagnosis] myocardial infarction Morange PE et al. Arterioscler Thromb Vasc Biol. 2007
NM_000602.5:c.-675A>G genomics myocardial infarction[diagnosis] myocardial infarction Eriksson P et al. Proc Natl Acad Sci U S A. 1995
NM_000602.5:c.-675A>G genomics myocardial infarction[diagnosis] myocardial infarction Ossei-Gerning N et al. Arterioscler Thromb Vasc Biol. 1997
NM_000602.5:c.-675A>G genomics acute myocardial infarction[diagnosis] acute myocardial infarction Mikkelsson J et al. Thromb Haemost. 2000
NM_000602.5:c.-675A>G genomics myocardial infarction[diagnosis] myocardial infarction Fu L et al. Chin Med J (Engl). 2001
NM_000602.5:c.-675A>G genomics acute myocardial infarction[diagnosis] acute myocardial infarction Hindorff LA et al. J Cardiovasc Risk. 2002
NM_000602.5:c.-675A>G genomics myocardial infarction[diagnosis] myocardial infarction Yamada Y et al. N Engl J Med. 2002
NM_000602.5:c.-675A>G genomics myocardial infarction[diagnosis] myocardial infarction Aucella F et al. Nephrol Dial Transplant. 2003
NM_000602.5:c.-675A>G genomics myocardial infarction[diagnosis] myocardial infarction Leander K et al. Thromb Haemost. 2003
NM_000602.5:c.-675A>G genomics myocardial infarction[diagnosis] myocardial infarction Juhan-Vague I et al. J Thromb Haemost. 2003
NM_000602.5:c.-675A>G genomics acute myocardial infarction[diagnosis] acute myocardial infarction Onalan O et al. J Thromb Thrombolysis. 2008
NM_000602.5:c.-675A>G genomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Isordia-Salas I et al. Rev Esp Cardiol. 2009
NM_000602.5:c.-675A>G genomics acute myocardial infarction[diagnosis] acute myocardial infarction Rallidis LS et al. J Thromb Thrombolysis. 2010
NM_000602.5:c.-675A>G genomics myocardial infarction[diagnosis] myocardial infarction Ahmed W et al. Mol Biol Rep. 2011
NM_000602.5:c.-675A>G genomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Santiago-German D et al. J Thromb Thrombolysis. 2012
NM_000602.5:c.-675A>G genomics no-reflow phenomenon[prognosis (bad)] acute ST elevation myocardial infarction Ozkan B et al. Coron Artery Dis. 2012
NM_000602.5:c.-675A>G genomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Cagliyan CE et al. Coron Artery Dis. 2013
NM_000602.5:c.-675A>G genomics death[prognosis (bad)] acute myocardial infarction Abd El-Aziz TANA Rezk Cell Biochem Biophys. 2015
NM_000602.5:c.-675A>G genomics acute myocardial infarction[diagnosis] acute myocardial infarction Abd El-Aziz TANA Rezk Cell Biochem Biophys. 2015
NM_000602.5:c.-675A>G genomics coronary occlusion[prognosis (bad)] myocardial infarction Parpugga TK et al. Dis Markers. 2015
NM_000602.5:c.-675A>G genomics myocardial infarction[diagnosis] myocardial infarction Hassani Idrissi H et al. Meta Gene. 2016
NM_000602.5:c.-675A>G genomics myocardial infarction[diagnosis] myocardial infarction Osmak GJ et al. Russian. 2020
NM_000602.5:c.-675A>G genomics myocardial infarction[diagnosis] myocardial infarction Abboud N et al. Genet Test Mol Biomarkers. 2010
plasminogen activator inhibitor 1 proteomics adverse events[prognosis (bad)] acute myocardial infarction El-Menyar AA et al. Coron Artery Dis. 2006
plasminogen activator inhibitor 1 proteomics adverse events[prognosis (bad)] acute myocardial infarction Islam S et al. Int J Clin Exp Med. 2014
plasminogen activator inhibitor 1 proteomics good predictor type 2 diabetes mellitus[prognosis (bad)] ST elevation myocardial infarction Barbarash O et al. Arch Med Sci. 2017
tissue plasminogen activator/plasminogen activator inhibitor-1 complex proteomics myocardial infarction[diagnosis] myocardial infarction Nordenhem A et al. Thromb Res. 2005
tissue plasminogen activator/plasminogen activator inhibitor-1 complex proteomics myocardial infarction[diagnosis] myocardial infarction Nordenhem A et al. Thromb Res. 2005
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